Serosurvey of hepatitis B surface antigen in pregnant Saudi women

In 1990, Saudi Arabia began vaccinating all children at school entry against hepatitis B. We evaluated hepatitis B surface antigen [HBsAg] prevalence rate among pregnant Saudi women 12 years later in 5 regions of the country. Using multistage sampling, 2664 pregnant Saudi women were recruited. Blood samples were tested for HBsAg; positive samples were also tested for hepatitis Be antigen [HBeAg]. In all 2.44% were positive for HBsAg and 4 [0.15%] were also positive for HBeAg. HBsAg prevalence was highest in Gizan [4.2%] and lowest in Tabuk [1.4%]. Positivity for women < or = 20 years of age was 0.5% compared with 2.6% for older women [P = 0.049]. The overall HBsAg prevalence rate was lower than previously reported

Feeding practice outcome for preterm infants in two neonatology units in Buraidah, Saudi Arabia

We carried out a follow-up study to investigate variation in short-term outcome for preterm infants in 2 hospitals in Buraidah. We compared gestational age, birth weight, head circumference at birth and length of stay. Outcome measures were weight gain/day, feeding pattern on discharge and feeding pattern 1 month after discharge. Mean weight gain was significantly higher in hospital A, 9.6 [ +/- 19.7] g/day compared to -1.2 [ +/- 29.5] g/day in hospital B [P = 0.049]. The proportion of infants exclusively breastfed 1 month after discharge was 37.5% in hospital B compared to 13.2% in hospital A [P = 0.0224]. There are clear hospital level differences in short-term outcome in the same region, emphasizing the need for continuous follow-up and evaluation of differences in a perinatal audit

Effect of gender on reporting of MMR adverse events in Saudi Arabia

We evaluated the safety of a measles-mumps-rubella [MMR] immunization campaign for Saudi children [age range: 6-13 years] and gender differences in reporting post-MMR adverse events. After vaccinations were administered, we monitored 160 schools for 14 days and 19 hospitals in the 8 cities under study for 10 weeks. Incidence rates were: all MMR adverse events, 26.5/10,000 MMR vaccines [significantly higher in females than males]; Urabe strain aseptic meningitis, 1.0/295,000; fever, 40.2/10,000 [females] and 0.9/10,000 [males]; and parotitis, 5.4/10,000 [females] and 0.9/10,000 [males]. Combined MMR vaccine containing the Urabe mumps strain was safe for children aged 6-13 years. Gender differences regarding reactogenicity were evident and should be considered when designing future studies

Vaccines: World Health Organization versus Federal Drug Administration recommended formula

Vaccines produced in accordance with WHO formulas, differ in concentration from those used in United States according to FDA formulas. We aimed to compare the immunogenicity of both formulas. Infants who were 6 weeks old were randomly put into 3 groups to receive 3 doses of vaccines at 6 weeks, 3 months and 5 months of age. The vaccines consisted of Haemophilus influenzae type b vaccine, diphtheria-tetanus-pertussis and oral polio vaccine. Antibody levels for polyribosylribitol phosphate [PRP], tetanus, diphtheria and poliovirus were measured 1 month after the third dose of vaccines. Although diphtheria and tetanus antigens in the FDA formula are half the concentration of the WHO formula, anti-tetanus and anti-diphtheria antibodies were significantly higher. No difference was found between groups regarding oral poliovirus vaccine

Impact of health education program on knowledge about AIDS and HIV transmission in students of secondary schools in Buraidah City, Saudi Arabia: an exploratory study

Accurate information about acquired immunodeficiency syndrome [AIDS] and human immunodeficiency virus [HIV] is important for their prevention.This study is intended to assess knowledge on AIDS in students of secondary schools in Buraidah City and to measure the effect of a health education program on their knowledge about AIDS in general, modes of HIV transmission and the degree of their misperception about the transmission of the disease through casual contact. A well-designed health education program using personal communication and visual media techniques was conducted for 483 secondary school students in Buraidah secondary schools during the year 1997. Pre- and post-tests were done to examine their knowledge about AIDS.The results of this study pointed out that a health education program on AIDS for students of secondary schools greatly and significantly improved their scores on general knowledge on AIDS views on its transmission and misperception of AIDS [p < 0.01]. Continuous in-ice programs for secondary students are recommended